علوم زیستی دریا
Halimeh Rajabi; Hossein Zolgharnen; Ahmad Savari; Alireza Amouzandeh; Nabi Jomehzadeh
Abstract
In this paper, the venom apparatus of the marine cone snail C. frigidus that is peptide toxins manufacture section with pharmacological effect have been studied.The venom apparatus of about 6 specimens were removed and divided to 3 parts: The venom bulb, the proximal portions of the venom apparatus (close ...
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In this paper, the venom apparatus of the marine cone snail C. frigidus that is peptide toxins manufacture section with pharmacological effect have been studied.The venom apparatus of about 6 specimens were removed and divided to 3 parts: The venom bulb, the proximal portions of the venom apparatus (close to venom bulb), the distal portions of the venom apparatus (close to pharynx). Then were fixed in Bouin's for 48 hours and transferred to 70% ethanol. After dehydration and Paraffin embedded, they were cut by microtome, collected on glass slides, stained with Haematoxylin-Eosin and studied by light microscope. The results showed that the venom bulb has longitudinal, transversal muscles, and a row of cubic cells with round nuclei. The proximal and the distal parts are composed of elongated cylindrical cells with the basal ganglia. The epithelial cells of the venom apparatus have abundant granules and in the distal part that are larger than the proximal. The passageway between the lumen of the venom duct and the pharynx is a channel that lead to the radula bag containing radula with different degrees of a formation. So, C. frigidus venom production and delivery was performed by synthesis in the venom apparatus, storage toxin in the radula teeth and the venom injection is done by the venom bulb and the best section for toxin peptide extraction is the distal portion of the venom apparatus. The reason is that this part, is active in the secretion of mature toxins that can use for Medicinal purposes.